Immunopathology of necrotising scleritis

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منابع مشابه

Immunopathology of necrotising scleritis.

AIM To detect the immunohistopathology of necrotising scleritis. METHODS Immunohistochemical staining was performed on two groups of enucleated eyes with necrotising scleritis (systemic autoimmune disease and idiopathic scleritis). Deparaffinised sections were stained with CD3, CD20, CD68, CD8, CD4 and dendritic reticulum cells (DRC). RESULTS Within the autoimmune group, about 43% of inflam...

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Combined Infliximab and Rituximab in Necrotising Scleritis

We report a patient with necrotising scleritis in whom infliximab was used for short-term steroid-sparing while rituximab took effect. This enabled disease control without requiring an extended period of high-dose corticosteroid administration or the concurrent use of cyclophosphamide.

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Necrotising scleritis after bare sclera excision of pterygium.

AIM To report cases of scleral necrosis after simple pterygium excision in which adjunctive treatment was not used. METHODS We reviewed four patients who presented with scleral melt after pterygium excision without the use of adjunctive treatment in the form of beta irradiation, mitomycin C, or thiotepa. Each patient was thoroughly investigated to exclude underlying disease. RESULTS Certain...

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Chemotherapy-induced anterior necrotising scleritis: A case report

Purpose We describe a case of anterior necrotising scleritis secondary to Gemcitabine and Carboplatin chemotherapy agents in a patient with metastatic breast cancer, which has not been previously reported. Observations A 50-year-old lady with recurrent metastatic breast cancer presented with unilateral subconjunctival haemorrhage secondary to severe thrombocytopenia eight days following palli...

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Use of cyclosporin in the management of steroid dependent non-necrotising scleritis.

Many patients with non-necrotising scleritis can be treated adequately with non-steroidal anti-inflammatory drugs or steroids. But, as many of them are young, treatment may present problems if they require high doses of steroids to control the scleral inflammation and then relapse when the dosage is reduced. Five such patients were treated with a combination of steroids and low-dose cyclosporin...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 2008

ISSN: 0007-1161

DOI: 10.1136/bjo.2007.126425